404 Error on Activate / Deactivate Plugin

I have a standard WP install (3.5.1) and am trying to activate a new plugin (WP Super Cache) however each time I try to activate it, I get my site’s 404 error page… which is strange as it’s the same page (wp-admin/plugins.php) as the plugin list page I’m activating from, but with a query string. Stranger still is that I cannot deactivate, or activate any of my other plugins?!?

I haven’t changed the .htaccess file or made any changes to the permalink structure and can’t seem to nail down what is going on?

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There doesn’t seem to be any resource on this anywhere; anyone have any ideas?

Any help would be greatly appreciated!

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  1. For anyone running into a similar problem, it came down to a plugin conflict; in my case Capability Manager Enhanced and Access which is part of the Toolset plugin. Unfortunately no error_log of /var/log/httpd log files were generated as it was an internal permissions conflict within WordPress.

    If you find yourself in this situation, simply FTP / SSH into the server and rename / delete the plugin you don’t want from the /wp-content/plugins/ directory and reload your Admin -> Plugins page.

    I hope this helps someone!