Multisite, domain mapping and SSL?

I have been doing alot of research and everything on the subject seems to be one of areas where everyone is finding some sort of different solution.
I am setting up a network something like edublogs.com and some sites will have mapped domains. I need to have some pages secured for the sites. These pages include some custom admin user profiles pages and checkout pages for a simple shopping cart/store system.
I am not looking for how to set it up, but if it is possible on a multisite and if anyone here has personaly accoumplished it succsesfully?
Thanks

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