Downsize CPU & DB usage in wordpress

i have created a smart interface WP based which we use to manage clients..
it uses a lot of information and data each time a client is returned / viewed.

it is a locked interface and does not have traffic spikes

in the past month i have seen major memory and CPU usage spikes so,
i have installed the debug bar and opended all the options.

What i am seeing is that each time wordpress includes wp-header-blog
and template-loader (or am i wrong?) – can i declare those once?

here is an example from the queries tab in the debug bar

'clientsocialurls'
require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/sagive-manager/category.php'), include('/themes/sagive-manager/tabs/tab-siteinfo.php'), get_page_by_title #47 (14.4ms)
SELECT ID FROM armnd_posts WHERE post_title = 'זמנהוף שירותי תרגום' AND post_type= 'cheques'

require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/sagive-manager/category.php'), include('/themes/sagive-manager/tabs/tab-cheques.php'), get_page_by_title #48 (3.9ms)
SELECT armnd_posts.* FROM armnd_posts WHERE 1=1 AND armnd_posts.post_type = 'attachments' AND (armnd_posts.post_status = 'publish') ORDER BY armnd_posts.post_date ASC 

require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/sagive-manager/category.php'), include('/themes/sagive-manager/tabs/tab-attachments.php'), get_posts, WP_Query->query, WP_Query->get_posts #49 (34.7ms)
SELECT post_id, meta_key, meta_value FROM armn_postmeta WHERE post_id IN (2073,2086,2093,2104,2109,2114,2119,2137,2143,2148,2154,2160,2165,2174,2178,2186,2274,2650,2708,3163,3356,3507,3644,3673,3893,3924,4039,4139,4286,4311,4515,4596,4666,4698,4722,4738,4740,4841,4860,4908,5219,5941,6086,6317) ORDER BY meta_id ASC

require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/sagive-manager/category.php'), include('/themes/sagive-manager/tabs/tab-attachments.php'), get_posts, WP_Query->query, WP_Query->get_posts, update_post_caches, update_postmeta_cache, update_meta_cache #50 (9.9ms)
SELECT armnd_posts.* FROM armnd_posts WHERE 1=1 AND armnd_posts.post_parent = 2119 AND armnd_posts.post_type = 'attachment' AND (armnd_posts.post_status = 'inherit') ORDER BY armnd_posts.post_date DESC 

require('wp-blog-header.php'), require_once('wp-includes/template-loader.php'), include('/themes/sagive-manager/category.php'), include('/themes/sagive-manager/tabs/tab-attachments.php'), get_posts, WP_Query->query, WP_Query->get_posts

does this means wordpress loads both files each time a query is called?
can i “Declare” them once to minimize memory usage and load time?

am i completlty missing the point and can you share some tips to downsize
the CPU usage & memory usage if its a given i cant use caching plugin.